創薬産業構造解析コンソーシアム
蛋白質構造解析コンソーシアム

  学術論文
Investigation of the Histamine H3 Receptor Binding Site. Design and Synthesis of Hybrid Agonists with a Lipophilic Side Chain.
Makoto Ishikawa, Takashi Watanabe, Toshiaki Kudo, Fumikazu Yokoyama, Miki Yamauchi, Kazuhiko Kato, Nobukazu Kakui and Yasuo Sato.
J. Med. Chem., 2010, 53 (17), pp 6445?6456.
The importance of CH/pi hydrogen bonds in rational drug design: An ab initio fragment molecular orbital study to leukocyte-specific protein tyrosine (LCK) kinase.
Ozawa T, Tsuji E, Ozawa M, Handa C, Mukaiyama H, Nishimura T, Kobayashi S, Okazaki K.
Bioorg Med Chem. 2008 Dec 15;16(24):10311-8.

Discovery of novel 2-anilinopyrazolo[1,5-a]pyrimidine derivatives as c-Src kinase inhibitors for the treatment of acute ischemic stroke.
Mukaiyama H, Nishimura T, Shiohara H, Kobayashi S, Komatsu Y, Kikuchi S, Tsuji E, Kamada N, Ohnota H, Kusama H.
Chem Pharm Bull (Tokyo). 2007 Jun;55(6):881-9.

Structural analysis of human glutamine:fructose-6-phosphate amidotransferase,a key regulator in type 2 diabetes
Y. Nakaishi, M. Bando, H. Shimizu, K. Watanabe, F. Goto, H. Tsuge,K. Kondo and M. Komatsu:
FEBS letters. (2009). 583, 163-167
Solid - Liquid Equilibria in an l-Isoleucine + l-Alanine + Water System
Toshimichi Kamei, Kazuhiro Hasegawa, Tatsuki Kashiwagi, Eiichiro Suzuki, Masaaki Yokota, Norihito Doki and Kenji Shimizu
J. Chem. Eng. Data, 2008, 53 (12), pp 2801-2806
Solid - Liquid Equilibria in an l-Isoleucine + l-Norleucine + Water System
Toshimichi Kamei, Kazuhiro Hasegawa, Tatsuki Kashiwagi, Eiichiro Suzuki, Masaaki Yokota, Norihito Doki and Kenji Shimizu
J. Chem. Eng. Data, 2008, 53 (6), pp 1338-1341
Mechanism of Mutual Incorporation of l-Isoleucine and Isomorphic Amino Acids in Batch Crystallization
Toshimichi Kamei, Kazuhiro Hasegawa, Tatsuki Kashiwagi, Eiichiro Suzuki, Masaaki Yokota, Norihito Doki and Kenji Shimizu
Org. Process Res. Dev., 2008, 12 (5), pp 850-854
Crystal structure of enoyl-acyl carrier protein reductase (FabK) from Streptococcus pneumoniae reveals the binding mode of an inhibitor
Jun Saito, Mototsugu Yamada, Takashi Watanabe, Maiko Iida, Hideo Kitagawa, Sho Takahata, Tomohiro Ozawa, Yasuo Takeuchi, and Fukuichi Ohsawa
Protein Science. (2008). 17, 691-699
Crystallization and preliminary crystallographic analysis of the transpeptidase domain of penicillin-binding protein 2B from Streptococcus pneumoniae
M. Yamada, T. Watanabe, N. Baba, T. Miyara, J. Saito and Y. Takeuchi
Acta Cryst. (2008). F64, 284-288
Crystal Structures of Biapenem and Tebipenem Complexed with Penicillin-Binding Proteins 2X and 1A from Streptococcus pneumoniae
Mototsugu Yamada, Takashi Watanabe, Nobuyoshi Baba, Yasuo Takeuchi, Fukuichi Ohsawa, and Shuichi Gomi
Antimicrob. Agents Chemother. (2008). 52, 2053-2060
Crystal Structure of Cefditoren Complexed with Streptococcus pneumoniae Penicillin-Binding Protein 2X: Structural Basis for Its High Antimicrobial Activity
Mototsugu Yamada, Takashi Watanabe, Takako Miyara, Nobuyoshi Baba, Jun Saito, Yasuo Takeuchi, and Fukuichi Ohsawa
AAC (2007). 51, 3902-3907
Structural Comparison of Fucosylated and Nonfucosylated Fc Fragments of Human Immunoglobulin G1
Shigeki Matsumiya, Yoshiki Yamaguchi, Jun-ichi Saito, Mayumi, Nagano, Hiroaki Sasakawa, Shizuo Otaki, Mitsuo Satoh, Kenya Shitara and Koichi Kato
J. Mol. Biol. (2007). 368, 767-779
Identification of a selective ERK inhibitor and structural determination
of the inhibitor-ERK2 complex

Makoto Ohori, Takayoshi Kinoshita, Mitsuru Okubo, Kentaro Sato,
Akiko Yamazaki, Hiroyuki Arakawa, Shintaro Nishimura, Noriaki Inamura,
Hidenori Nakajima, Masahiro Neya, Hiroshi Miyake, Takashi Fujii
BBRC (2005). 336, 357-363
Crystal structure of human ERK2 complexed with a
pyrazolo[3,4-c]pyridazine derivative

Takayoshi Kinoshita, Masaichi Warizaya, Makoto Ohori, Kentaro Sato,
Masahiro Neya and Takashi Fujii
Bio. Med. Chem. Lett. (2006). 16, 55?58
Makoto Ohori, Takayoshi Kinoshita, Seiji Yoshimura, Masaichi Warizaya,
Hidenori Nakajima, Hiroshi Miyake
BBRC (2007). 353, 633-637
Structure of a high-resolution crystal form of human triosephosphate isomerase: improvement of crystals using the gel-tube method
Takayoshi Kinoshita, Riyo Maruki, Masaichi Warizaya, Hidenori Nakajima and Shintaro Nishimura
Acta Cryst. (2005). F61, 346-349
Discovery of quinazolinone and quinoxaline derivatives as potent and selective poly(ADP-ribose) polymerase-1/2 inhibitors
Iwashita A, Hattori K, Yamamoto H, Ishida J, Kido Y, Kamijo K, Murano K, Miyake H, Kinoshita T, Warizaya M, Ohkubo M, Matsuoka N, Mutoh S.
FEBS Letters. (2005). 579, 1389-93
Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease
Tatsuya Horio, Masatoshi Murai, Toshihiko Inoue, Tomohiro Hamasaki, Teruo Tanaka and Tadaaki Ohgi
FEBS Letters. (2004). 577, 111-116
Expression, purification, crystallization and preliminary X-ray diffraction studies of human liver regucalcin
M. Warizaya, T. Kinoshita, M. Yamaoka, T. Shibata, N. Saito, H. Nakajima and T. Fujii
Acta Cryst. (2004). D60, 2019-2021
Rational Approaches to Discovery of Orally Active and Brain-Penetrable Quinazolinone Inhibitors of Poly(ADP-ribose)polymerase
K. Hattori, Y. Kido, H. Yamamoto, J. Ishida, K. Kamijo, K. Murano, M. Ohkubo,
T. Kinoshita, A. Iwashita, K. Mihara, S. Yamazaki, N. Matsuoka, Y. Teramura, &
H. Miyake
J Med Chem. (2004). 47, 4151-4154
The crystal structure of human dipeptidyl peptidase IV (DPPIV) complex with diprotin A
H. Hiramatsu, A. Yamamoto, K. Kyono, Y. Higashiyama, C. Fukushima, H. Shima,
S. Sugiyama, K. Inaka, and R. Shimizu
Biol. Chem. (2004). 385, 561-564
Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase
K. Kamata, M. Mitsuya, T. Nishimura, J. Eiki and Y. Nagata
Structure (2004). 12, 429-438
Cloning, expression, purification, crystallization and preliminary X-ray analysis of human liver glyceraldehyde-3-phosphate dehydrogenase
M. Warizaya, T. Kinoshita, A. Kato, H. Nakajima and T. Fujii
Acta Cryst. (2004). D60, 567-568